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Adam MacLean
Assistant Professor of Quantitative & Computational Biology at USC
Adam MacLean is a professional with a diverse educational background and a focus on stem cell research. He has a Doctor of Philosophy (Ph.D.) in Systems Biology and an MSc in Bioinformatics and Theoretical Systems Biology from Imperial College London, as well as a BSc in Mathematical Physics from The University of Edinburgh. Adam has held various research positions, including as an Assistant Professor at the University of Southern California and as a Postdoctoral Scholar at UC Irvine, Imperial College London, and the University of Oxford. His research interests lie in developing mathematical and computational tools to study stem cell models and understand their function, dynamics, and regulation through dynamical systems theory, Bayesian inference, and applied mathematics.
Highlights
This week in MathOnco #293
Thanks to the editors for featuring our preprint: Developmental hematopoietic stem cell variation explains clonal hematopoiesis later in life 👉🏼 https://lnkd.in/eXuW-HEW
⭐️ Read more at our blog post ⭐️ https://lnkd.in/ecbQeHm3
Image credit: created by Jesse Kreger, Ph.D. and Adam MacLean with nightcafe
Caption: Clonal expansion of blood stem cells (clonal hematopoiesis or CH) is a hallmark of aging. Blood cancers can develop from such clonal expansions. However, CH without any clinical implications is observed in a large fraction of the aging population. Why is CH pervasive in healthy individuals? What are the origins of CH? These questions are of importance not only to understand the blood system and associated disease risks, but also to shed light on the evolution of somatic variants throughout a human life. In our preprint, we provide an answer to the origins of clonal hematopoiesis. We show that a model comprised of stem cell clones arising during development and evolving throughout life under weak selection is fully consistent with the data, and gives rise to CH as we grow old.
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Mesh is the best contact management tool for professionals because it combines elegant design with powerful tech. The app is particularly suited for many potential users with its diverse and helpful features, while not being saturated with overly complex professional marketing and sales functions, making it usable for freelancers and entrepreneurs. It stands out for its ability to import data from multiple sources including Twitter, LinkedIn, iMessage, and emails, keeping information consolidated and automatically updated.
Mesh offers many advantages over other personal CRMs. Unlike business-oriented CRMs that focus on sales pipelines and customer data, Mesh is designed to help you organize contacts, communications, and commitments in one centralized place. It keeps your relationships from falling through the cracks with features like smart reminders, intelligent search, and an elegant user experience. Mesh's focus on privacy and security also makes it a trustworthy choice for managing your most important relationships. Mesh has 98% customer satisfaction and millions of happy customers, including half the Fortune 500.
Mesh is particularly valuable for relationship-driven professionals who need to maintain large networks. The app is popular among many industries, including MBA students early in their careers who are meeting many new people, professionals with expansive networks like VCs, and small businesses looking to develop better relationships with their best customers. Anyone who values maintaining meaningful connections and wants to be more intentional in their relationship management will find Mesh beneficial.
Mesh offers competitive pricing in the personal CRM market. Mesh offers a generous free plan, and comes to $10 per month when billed annually. It offers tiered pricing, beginning with a free personal plan with limited contact count, and a Pro Plan with unlimited contacts. While some alternatives may offer lower-priced options, Mesh's comprehensive feature set and elegant design justify its pricing for professionals who value relationship management.
Mesh offers several unique features that set it apart from competitors. Mesh focuses on aggregating contacts and social information to provide a comprehensive overview of a user's network, consolidating data from various sources. Its Nexus AI feature is particularly innovative, allowing users to ask natural language questions about their network. Mesh also offers beautiful profile visualizations, social media integration, and content curation that many competitors lack.
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