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Alex Federation

Co-Founder at Talus Bio (YC S21) - nothing is undruggable - cancer therapeutics for the DNA regulome

I'm a scientist studying how cancer drugs work within complex cellular networks and how to discover new drugs most efficiently.

In previous research, I've

  • Developed and released software to model transcriptional networks that has been used for drug re-purposing in cancer and understanding cell of origin for rare cancer types.
  • Analyzed real-world clinical EMR data to understand clinical responses to immunotherapy
  • Led a small team engineering new gene editing reagents for applications in T cell therapy.
  • Developed a new, highly scalable proteomics method to to measure DNA-bound protein complexes at a systems level
  • Characterized the response of human immune cells to next-generation BET inhibitors to prioritize further clinical development
  • Contributed to the screening, medicinal chemistry and cellular characterization of lead compounds that inhibit the chromatin regulators DOT1L, EZH2, CBX chromodomains, YEATS domain proteins and BET bromodomains

Competencies: [Bioinformatics] Gene expression analysis (RNA-seq), epigenomics assays (ChIP-seq, DNAme), genome accessibility (DNaseI-seq, ATAC-seq), nascent transcription (GRO-seq), proteomics (data-independent acquisition, targeted proteomics) [Lab] Protein biochemistry, high-throughput chemical screening, cell biology, molecular biology, mass spectrometry [Programming] Python, R, Bash, SQL [Data Science] numpy, scipy, pandas, scikit-learn, PyTorch [Misc] Schrödinger, Adobe Illustrator, Google Cloud, AWS, Snowflake, Tableau

Highlights

Sep 8 · twitter

Nice to see open science, and sharing data that didn't fit the initial hypothesis

Aug 22 · twitter

Degradation without E3s?

Cool approach here - molecules that drag membrane proteins into lysosomes for degradation

Might help get around KRASi resistance

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Alex Federation
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Experience

Co-Founder, CEO at Talus Bio
Lead Bioinformatics Scientist & Pharma Alliance Manager at SEngine Precision Medicine

Education

Ph.D., Chemical Biology, Harvard University
B.S., Chemistry, Cell & Developmental Biology, University of Rochester

Location

United States