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Alex Federation

Co-Founder at Talus Bio (YC S21) - nothing is undruggable - cancer therapeutics for the DNA regulome

Alex Federation, Ph.D. is the co-founder and CEO of Talus Bio, a biotechnology company focused on developing innovative cancer therapeutics.12 He invented the MARMOT platform during his postdoctoral fellowship at the Altius Institute for Biomedical Research in Seattle, where he trained in computational epigenomics and cancer biology.2

Dr. Federation's background includes:

  1. Education:

    • Ph.D. in Chemical Biology from Harvard University3
    • B.S. in Chemistry, Cell & Developmental Biology from the University of Rochester3
  2. Professional Experience:

    • Co-founder and CEO of Talus Bio since October 20203
    • Previously worked as Lead Bioinformatics Scientist & Pharma Alliance Manager at SEngine Precision Medicine3
    • Senior Data Scientist at Navigating Cancer3
    • Research Fellow at Altius Institute for Biomedical Sciences3
  3. Research Focus:

    • Targeting previously "undruggable" transcription factors for cancer drug discovery1
    • Leveraging advanced methods such as functional proteomics, machine learning, and automated biology13

Under Alex's leadership, Talus Bio employs their MARMOT platform, which integrates AI, proteomics, and automation to enable transcription factor drug discovery at scale.1 The company aims to create first-in-class drugs with high potency and selectivity while minimizing toxicity.1

Dr. Federation is known for his belief that "nothing is undruggable," a philosophy that drives Talus Bio's innovative approach to drug discovery.13

Highlights

Sep 8 · twitter

Nice to see open science, and sharing data that didn't fit the initial hypothesis

Aug 22 · twitter

Degradation without E3s?

Cool approach here - molecules that drag membrane proteins into lysosomes for degradation

Might help get around KRASi resistance

Related Questions

What inspired Alex Federation to pursue a career in biotechnology?
How did Alex Federation's training at Harvard influence his work at Talus Bio?
What is the MARMOT platform, and how does it work?
How does Talus Bio's approach to drug discovery differ from other companies?
What are some of the challenges Alex Federation has faced in developing cancer therapeutics?
Alex Federation
Alex Federation, photo 1
Alex Federation, photo 2
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Location

Seattle, Washington, United States