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Blair Benham-Pyle
Cell Biologist - Cancer Biologist - Aging and Regeneration Research
Blair Benham-Pyle is a cell biologist and cancer researcher currently working as a Jane Coffin Childs Postdoctoral Research Fellow at the Stowers Institute for Medical Research.12 She holds a PhD in Cancer Biology from Stanford University, where she studied mechanical signaling in skin cells.4 Her current research focuses on aging and regeneration in planarian flatworms, particularly investigating size control and scaling during planarian regeneration and growth.
Benham-Pyle's academic journey began at Yale University, where she earned a joint B.S./M.S. in Molecular Biophysics and Biochemistry.4 During her time at Yale, she participated in research projects analyzing rainforest endophytes as potential sources of novel antibiotics and anthelmintics.4
After completing her PhD, Benham-Pyle was awarded the prestigious Jane Coffin Childs Postdoctoral Fellowship in 2017.12 Her postdoctoral work involves using a combination of sequencing and quantitative imaging techniques to study regeneration in planarian worms.2 This research aims to identify the minimal cell types and tissue structures required for complete regeneration and accurate scaling, potentially revealing novel mechanisms regulating self-organization and growth in resource-limited adult tissues.2
Benham-Pyle has made significant contributions to her field, including adapting a new single-cell sequencing method (SplitSeq) for large-scale gene-expression studies in planaria.3 Her work has led to the discovery of transient regeneration-activating cell states (TRACS) and insights into the roles of different cell types in the regeneration process.3
Outside of her research, Benham-Pyle is passionate about mentoring young scientists and exploring the interface of science, business, and society.4 She continues to enjoy volleyball, a sport she played competitively during her time at Yale.4

