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Bryan Johnson
Founder & CEO of Blueprint
It appears there might be a mix-up in the LinkedIn username provided. The correct LinkedIn username for Bryan Johnson, Founder/CEO of Blueprint, is bryanrjohnson, not brian10.
Bryan Johnson is a renowned American entrepreneur and venture capitalist known for his innovative ventures in science and technology. Here's a brief overview of his career and achievements:
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Early Life and Education: Born on August 22, 1977, in Provo, Utah, Johnson grew up in Springville, Utah. He graduated from Brigham Young University with a BA in International Studies and later earned an MBA from the University of Chicago Booth School of Business.4
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Career Highlights:
- Braintree and Venmo: Johnson founded Braintree in 2007, which became a leading online payment system. Braintree acquired Venmo in 2012, and the combined entity was sold to PayPal for $800 million in 2013.4
- OS Fund: In 2014, he launched OS Fund, a venture capital firm focused on early-stage science and technology companies.4
- Kernel: Founded in 2016, Kernel develops devices to monitor brain activity, aiming to advance understanding of neurological conditions.4
- Blueprint: Johnson's most recent initiative is Blueprint, a lifestyle program aimed at reversing aging through personalized health strategies. He initiated Project Blueprint in 2020 as a $2 million-per-year experiment to optimize his health.3
Bryan Johnson is also known for his anti-aging efforts and claims to be the "healthiest man on the planet" through his rigorous regimen of diet, exercise, and medical interventions.12
Highlights
The longevity dose for sleep is 6.4 - 7.8 hours.
23 biological aging clocks multi-omics: 11 proteomic, 5 metabolomic, 7 MRI 500,000 people
Interesting findings:
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Brain proteins notice sleep loss before brain anatomy does. When you measure brain aging by plasma proteins, the brain looks biologically youngest at 7.82 hours of sleep in women and 7.70 hours in men. When you measure brain aging by MRI of brain anatomy, it looks youngest at 6.48 hours in women and 6.42 hours in men.
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The brain and the metabolic organs share the same U-shape but hit their optimum at different hours. Fat tissue and the pancreas both bottomed near 6 hours. The brain bottomed higher, between 6.4 and 7.8 hours depending on whether you measure by MRI or plasma proteins. Sleep less or more than the organ-specific optimum and aging accelerates.
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Short sleepers vs long sleepers DNA.
Short sleepers' DNA matched the DNA of people whose bodies are breaking down all over.
back pain 40% depression 37% substance use disorders 37% anxiety 32% heart failure 31% lung disease 28% type 2 diabetes 18%.
Looking at genes only, chronically too little sleep makes the body look like it's breaking down everywhere.
Long sleepers' DNA matched the DNA of people with brain conditions versus whole body breakdown.
major depression 29% schizophrenia 28% ADHD 28%, migraine 28% bipolar disorder 21%
Short sleep gets you through the body directly: the nervous system get's aggravated, the immune system gets confused and stress hormones flood the bloodstream.
Long sleep get's you through the brain, but it's the result and not the cause. By the time someone is sleeping too long, the damage is already happening inside their organs.
Summary:
Less than 6.4 hours is a stressor. Your body is wearing down because it never gets enough time to recover. The short sleep is what is causing the damage.
More than 7.8 hours is a warning sign, signaling that something is already going wrong in your brain or your metabolic organs.


