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James R. Downing, M.D.

President and CEO of St. Jude Children's Research Hospital

James R. Downing, M.D. is a distinguished medical professional and leader in pediatric cancer research who currently serves as the President and Chief Executive Officer of St. Jude Children's Research Hospital.1 He assumed this role in July 2014, marking a significant milestone in his long-standing career with the institution.5

Career at St. Jude

Dr. Downing's association with St. Jude spans several decades, during which he has held various leadership positions:

  • President and CEO (2014 - Present)
  • Scientific Director and Executive Vice President (2004 - 2014)
  • Chair, Department of Pathology (1997 - 2009)
  • Member, Department of Pathology (1997 - Present)
  • Associate Member, Department of Pathology (1991 - 1997)
  • Assistant Member, Department of Pathology and Laboratory Medicine (1986 - 1991)1

Education

Dr. Downing received his medical education from the University of Michigan, where he earned his Doctor of Medicine (M.D.) degree. He also holds a Bachelor of Science (B.S.) from the University of Michigan-Dearborn.1

Research and Publications

As a prolific researcher, Dr. Downing has made significant contributions to the field of pediatric cancer. He has authored more than 270 papers in peer-reviewed journals, including prestigious publications such as Nature Genetics, New England Journal of Medicine, and Blood.1 His work has been instrumental in advancing our understanding of pediatric cancers and developing new treatment strategies.

Awards and Honors

Throughout his career, Dr. Downing has received numerous accolades for his contributions to cancer research and leadership in healthcare:

  • Fellow of the American Association for Cancer Research (2022)
  • Outstanding Achievement in Pediatric Cancer Research Award (2020)
  • CEO of the Year by Inside Memphis Business (2020)
  • Pediatric Oncology Award and Lecture from the American Society of Clinical Oncology (2019)
  • E. Donnall Thomas Lecture & Prize from the American Society of Hematology (2017)
  • Member of the American Academy of Arts and Sciences (2016)
  • Member of the National Academy of Medicine (2013)1

Leadership and Vision

Under Dr. Downing's leadership, St. Jude has embarked on ambitious initiatives, including a $12.9 billion commitment to advance research and treatment of pediatric cancers.2 He is known for fostering a positive work environment, as evidenced by St. Jude's recognition as one of Glassdoor's Best Places to Work.3

Dr. Downing is not only dedicated to his professional pursuits but also maintains personal interests outside of work. He has been known to participate in cycling events, demonstrating a commitment to physical fitness and work-life balance.4

Highlights

Aug 21 · linkedin

At St. Jude, every discovery is a step closer to the day when no child dies in the dawn of life.

I invite you to read about the incredible work our researchers have done over the past year in our recently released annual scientific report, “Translating Science Into Survival.”

The report details how we have been using CRISPR technology to revolutionize biomedical research for cancer and exploring gene-editing for new strategies against sickle-cell disease. We are investing in understanding protein structure to develop new treatments for brain tumors and exploring the viruses, bacteria and fungi that pose a risk to patients.

Walking the halls of St. Jude Children's Research Hospital, I sometimes think about all the life-saving research that has taken place here over the past 60-plus years. Each breakthrough, at the bench or the bedside, brings us a step closer to realizing our mission of advancing cures and means of prevention for childhood catastrophic diseases.

Aug 20 · linkedin

We were saddened to learn that Phil Donahue, longtime television show host, St. Jude champion, and husband to our National Outreach Director Marlo Thomas died Sunday. Even as we grieve his loss, we celebrate Phil’s tireless work on behalf of the patients and mission of St. Jude.   Phil became a pioneer of the issues-based daytime talk show when he launched his first TV show in 1967. “The Phil Donahue Show” rocketed in popularity, making “Donahue” a household name across America. In 1977, he met Marlo while she was a guest on his show, and the couple later said it was “love at first sight.” They were married for 44 years.

His example of selfless service, unending generosity, and constant love have inspired millions of people throughout his life. Whether it was visiting patients, raising funds for St. Jude, or supporting the FedEx St. Jude Championship, he was always ready to do what he could to help advance cures and treatment of childhood illnesses.   I hope you’ll join me in remembering Phil and offering our heartfelt condolences to Marlo and his family during this difficult time.

Related Questions

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James R. Downing, M.D.
James R. Downing, M.D., photo 1
James R. Downing, M.D., photo 2
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Experience

President and Chief Executive Officer at St. Jude Children's Research Hospital since 2014
Various positions at St. Jude Children's Research Hospital including Scientific Director and Executive Vice President (2004-2014), Chair, Department of Pathology (1997-2009)

Education

Doctor of Medicine (M.D.) from University of Michigan; Bachelor of Science (B.S.) from University of Michigan-Dearborn

Location

Memphis Metropolitan Area