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Jeff Marrazzo

Co-Founder and Former Founding CEO of Spark Therapeutics

Jeff Marrazzo is a prominent figure in the biotechnology and healthcare industry, known for his entrepreneurial success and leadership in gene therapy. He joined the Board of Trustees at Children's Hospital of Philadelphia (CHOP) in July 2023.4

Marrazzo is best known for co-founding and leading Spark Therapeutics, a gene therapy company that grew from a research center within CHOP to a fully integrated commercial entity.12 Under his leadership, Spark achieved several milestones:

  1. Received regulatory approval for the first gene therapy for a genetic disease in both the U.S. and EU.2
  2. Launched the first gene therapy for a genetic disease in the United States.2
  3. Grew the company to over 850 employees.3
  4. Orchestrated Spark's $4.8 billion sale to Roche in 2019, marking a 100-fold increase in the company's market value over six years.4

Prior to Spark, Marrazzo worked on building a genetic testing benefit management company and served as an advisor to former Pennsylvania Governor Edward G. Rendell, focusing on healthcare financing and delivery reforms.12

Marrazzo's educational background includes:

  • B.A. in economics and B.S.E. in systems science and engineering from the University of Pennsylvania
  • Dual M.B.A./M.P.A. from The Wharton School of the University of Pennsylvania and Harvard University (a program he founded)13

Currently, Marrazzo serves on the boards of several start-up companies, including Chroma Medicine and Prime Medicine, as well as non-profit organizations like CHOP and Life Science Cares.34 In 2022, he and his wife founded the Marrazzo Family Foundation to foster creativity in Philadelphia youth.3

Related Questions

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Jeff Marrazzo
Jeff Marrazzo, photo 1
Jeff Marrazzo, photo 2
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Location

Philadelphia, Pennsylvania, United States