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Jocelynn Pearl

Senior Scientist at Tune Therapeutics & Host of Lady Scientist Podcast

Professional Background

Dr. Jocelynn Pearl is an accomplished scientist with a rich history in the field of genome editing and cellular therapy. Her career began at Sangamo Therapeutics, Inc., where she worked on zinc finger nucleases (ZFNs) and zinc finger protein transcription factors (ZFP-TFs), focusing on their optimization for research as well as translational purposes. This foundational experience set the stage for her future endeavors in molecular biology and genetic engineering.

After earning her Bachelor of Arts in Integrative Biology from the prestigious University of California, Berkeley, Jocelynn continued her academic pursuit by obtaining a Doctor of Philosophy (PhD) in Molecular and Cellular Biology from the University of Washington. Here, she had the unique opportunity to work under the mentorship of renowned scientists Dr. Leroy Hood and Dr. Nathan Price at the Institute for Systems Biology. Her dissertation was a pioneering effort that combined experimental and computational tools in systems genomics to unravel the complexities of gene regulation in neurologic diseases, showcasing her ability to bridge the gap between theoretical research and practical applications.

In the course of her postdoctoral fellowship at the Altius Institute of Biomedical Sciences in Seattle, Jocelynn honed her expertise by engineering proteins for both gene editing and epigenome editing applications, displaying particular interest in enhancing CAR T cell therapies. Her collaborative spirit and innovative approach led her to join Lyell Immunopharma in January 2019 as a Senior Scientist and Project Lead, where she effectively integrated both de novo and natural proteins in efforts to engineer novel cellular therapies.

In September 2020, further advancing her career, she became a part of Tune Therapeutics as a Senior Scientist. This role aligns with her vision to propel epigenome engineering initiatives into clinical applications, significantly impacting treatment options in the field of genetic diseases. Tune Therapeutics has distinguished itself under the leadership of co-founders Dr. Charles Gersbach and Dr. Fyodor Urnov, who are highly regarded within the scientific community.

Education and Achievements

Dr. Pearl pursued her education at two top-tier institutions. Her academic journey began at the University of California, Berkeley, where she earned her BA in Integrative Biology, solidifying her foundation in the biological sciences. Her academic excellence continued at the University of Washington, where she completed her PhD in Molecular and Cellular Biology. During her doctoral studies, she contributed substantially to the field of systems genomics, paving the way for innovations in gene regulation research relevant to neurologic diseases.

Throughout her career, Jocelynn has held various influential roles, notably as Host & Producer of the Lady Scientist Podcast. This platform expresses her passion for science communication and engagement with a broader audience, shedding light on the experiences of women in science and fostering greater inclusivity within the STEM community.

Her experience as a Senior Scientist and Project Lead at Lyell Immunopharma and her current role at Tune Therapeutics underscore her position as a prominent figure in the biomedical field. Her multifaceted skills in protein engineering and cellular therapy development have allowed her to contribute to cutting-edge therapeutic strategies aimed at improving patient outcomes.

Notable Achievements

  • Pioneered research in genome editing at Sangamo Therapeutics, contributing to the optimization of zinc finger nucleases.
  • Earned a PhD from the University of Washington, focusing on systems genomics and gene regulation in neurologic diseases.
  • Conducted innovative research on enhancing CAR T cell therapies during her postdoctoral fellowship.
  • Joined Lyell Immunopharma as a Senior Scientist, leading efforts to integrate novel protein strategies in cellular therapies.
  • Currently serving as a Senior Scientist at Tune Therapeutics, leading epigenome engineering research initiatives.
  • Spearheaded the production of the Lady Scientist Podcast, highlighting female scientists' contributions and experiences in academia and beyond.

title

Dr. Jocelynn Pearl: A Leader in Genome Editing and Cellular Therapy Research

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Location

Seattle, Washington, United States

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