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Jonathan O'Keeffe

CEO of Machine Medicine and expert in neurology and computational neuroscience

Jonathan O'Keeffe

Jonathan O'Keeffe is the CEO and Founder of Machine Medicine, a company building a platform for the development and deployment of precision neuro-therapeutics.12 He has a diverse background, including:

  • Doctor of Medicine (MD) from the University of Oxford
  • MSc in Machine Learning from University College London (UCL)
  • PhD in Computational Neuroscience from the University of Cambridge
  • Academic Clinical Fellow in Neurology at UCL
  • Wellcome Trust Clinical Fellow at the University of Cambridge

As a practicing neurologist, O'Keeffe saw the limitations of treating patients one-by-one. He wanted to combine his neurology and computer science expertise to have a deeper impact. This led him to found Machine Medicine, which combines AI, clinical knowledge, and ambition to solve problems in neurology.2

Machine Medicine's first product is Kelvin, a motor assessment platform for Parkinson's disease and other movement disorders. Kelvin-PD is being used in major clinical trials today.1 The company is building the software and data layer for precision neuro-therapeutics like deep brain stimulation.3

O'Keeffe has an impressive educational background, including degrees from Oxford, Cambridge, UCL, and the Royal College of Physicians.1 He is a native English speaker with limited working proficiency in French.1

Highlights

Aug 1 · linkedin

Frankly pretty disgusting to see Labour introducing 20% VAT on private school fees. So, now parents who want to work hard to provide a better level of education for their children than the drivel supplied (as usual) by the state sector will be additionally penalised (in additional to paying taxes that ostensibly pay for a state school place for their children)... it is apparently not enough that they already pay twice... the effect is to make private education still more the preserve of the very wealthy instead of an option for the aspiring and ambitious (as it should be)...

Jul 24 · linkedin

I was delighted to see Machine Medicine's motor assessment platform, Kelvin, used to provide a distributed DBS service between the Mater in Dublin and St George's in London, here shown to be non-inferior to localised services. And a nod to the AI-powered services that we will provide in the future, to drive neuromodulation into a predictive and personalised paradigm in which its availability and efficacy will be 1000-Xed.

"Cloud-based secure video storage with standardised and easily catalogued levodopa challenge data ensures both sites have a clear view on factors important for prediction of outcome and influencing target selection, in our case using Kelvin by Machine Medicine, which also gives the potential of artificial intelligence to aid in standardised UPDRS III rating of video examinations which may reduce inter-rater variability in the future."

Congrats to Eoghan Donlon, Erlick Pereira, Richard Walsh and the rest of the teams at St. George's University Hospital, London, and the Mater Hospital, Dublin, for this sterling work.

Related Questions

What inspired Jonathan O'Keeffe to combine neurology and computer science?
How does Kelvin-PD work in clinical trials for Parkinson's disease?
What are the main challenges Jonathan O'Keeffe faces as CEO of Machine Medicine?
How does Machine Medicine's approach differ from traditional neuro-therapeutics?
What is Jonathan O'Keeffe's educational background in neuroscience?
Jonathan O'Keeffe
Jonathan O'Keeffe, photo 1
Jonathan O'Keeffe, photo 2
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Experience

CEO at Machine Medicine (May 2017 - Present)
Advisory Board Member at MindBerry Group (March 2017 - April 2018), Academic Clinical Fellow in Neurology at UCL (August 2015 - March 2018)

Education

BA Medical Sciences, BM BCh, Physiology and Medicine, 1st at University of Oxford (2002 - 2008); Graduate Certificate in Theoretical Statistics and Probability at The Open University (2017 - 2018); Do

Location

London, England, United Kingdom