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Michael Florea
PhD Student at Harvard Medical School
Michael Florea is a highly accomplished professional in the field of biology, with a strong educational background and diverse research experience.
He holds a Doctor of Philosophy (PhD) in Biology/Biological Sciences from Harvard University, a Master of Science (MSc) in Biotechnology from Eidgenössische Technische Hochschule Zürich, and a Bachelor of Science (BSc) in Biology from Imperial College London.
During his academic journey, Michael has been actively involved in various prestigious organizations. He has contributed to research as a PhD Student at Harvard Medical School and as an MSc Student at Fussenegger Lab, D-BSSE, ETH Zürich.
Moreover, Michael has significant entrepreneurial experience, having co-founded Genetic Engineering R&D at CustoMem and served as the co-founder and President at SynBIC.
His professional journey also includes roles as an Undergraduate Student and Researcher at Imperial College London, as well as research positions at the Natural History Museum and the University of Zurich.
Michael Florea's multidisciplinary background and hands-on experience in both academia and industry underscore his expertise and passion for advancing the field of biology.
Highlights
Why would anyone leave a scientific career to go build ... mouse tech?
90.4% of drugs fail in humans. It costs $2.3B and takes 12 years to get a drug to market. Only ~50 new drugs are approved per year in the entirety of the US.
Animal studies determine what goes into humans. If you can reduce the failure rate by 2% (from 90% to 88%), resulting in 10 more drugs/year, you will have the impact of a major pharmaceutical conglomerate.
Many things can be done to improve translation that aren't being done. At the moment, we don't even know what works in mice, since at current economics, studies are rarely replicated.
Many more people should be thinking about this. Deep dive below.
Thank you to Cecilia Kruszynski de Assis for the insightful questions. https://lnkd.in/gBN-NUiq
A basic mouse longevity study costs half a million when outsourced.
That’s because the state of the art in animal research is measuring one animal at a time, by hand, and writing the data on a piece of paper. So, you need a team of technicians to get even a basic health dataset. As an example, in my PhD, I ran 4 studies - but it took me 8 full months of doing solely exhausting manual measurements all day, every day.
As a consequence, few quality studies are published each year. Most are underpowered. Very few are ever replicated. Yet a study in a mammal (usually mouse) is the data that people rely on to consider something potentially effective, and in longevity, try it on themselves. This is a fundamental bottleneck.
So today, exactly 1 year after my PhD defense, we’re launching Olden Labs - a company building the world's first automated animal lab. Our goal is to radically accelerate animal research for mankind, by bringing down the costs, time and accessibility barriers and removing the lack of reproducibility inherent in manual testing.
As our first technology, we’re releasing the DOME smart cage: a device that gives 24/7 data on 14+ metrics of animal’s health and can be installed in existing infrastructure. At <$1k, it is 30x cheaper than the nearest competitor, can measure multiple animals instead of one (no RFID), and can do this indefinitely instead of a few weeks max. We’ve used it to create the v1 of “digital bioage” - a metric that tracks the chronological age of animals by summarizing overall health. Accessible here: https://oldenlabs.com/
I’m incredibly fortunate to be joined by my co-founders Noah Weber (ex-CTO of CelerisTx and an AI 30U30), Michael Kaca (ex-Apple) and Pratomo Putra Alimsijah (ex-10x Genomics), and our external tech team Sead Delalić and Eldina Delalić (Uni. of Sarajevo) - the team behind this tech.
We’re also privileged to be supported by Charles Hirschler (CHBMR Partners, Harvard bioelectronics), Amy Wagers (Harvard Prof Stem Cell biology & aging), Kathleen Pritchett-Corning (Harvard Director of Animal studies), Vadim Gladyshev (Harvard Prof Systems Aging), Tyler Cowen (Mercatus Center’s Emergent Ventures), Nathan Cheng and Sebastian A. Brunemeier (Healthspan Capital), Niklas Anzinger (Infinita Fund), and many others. They make the highs worth it and the lows bearable. Finally, thanks to Danny Sullivan at Longevity Technology for the awesome article!
So, join us on the journey and let's make a dent.
https://lnkd.in/ggJ55VWE #longevity #animalresearch #biotechnology #AI
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Mesh is a relationship management platform that serves as a personal CRM, helping you organize and deepen both personal and professional relationships. It functions as a beautiful rolodex and CRM available on iPhone, Mac, Windows, and web, built automatically to help manage your network efficiently. Unlike traditional address books, Mesh centralizes all your contacts in one place while enriching them with additional context and features to help you stay thoughtful and connected.
Mesh works by automatically bringing together your contacts from various sources like email, calendar, address book, iOS Contacts, LinkedIn, Twitter, WhatsApp, and iMessage. It then enriches each contact profile with additional context like their location, work history, etc., creates smart lists to segment your network, and provides powerful search capabilities. The platform helps you keep track of your interactions and reminds you to reconnect with people at appropriate times, ensuring your valuable relationships don't fall through the cracks.
Mesh offers several powerful features including:
- Comprehensive Contact Management: Automatically collects contact data and enriches profiles to keep them up-to-date
- Network Strength: Visualizes the strength of your relationships relative to others in your network
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- Reminders and Notes: Helps you remember important details about contacts
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Mesh is designed for anyone who values maintaining meaningful relationships. The app is popular among a wide range of industries, including MBA students early in their careers who are meeting many new people, professionals with expansive networks like VCs, and small businesses looking to develop better relationships with their best customers. It’s even used by half the Fortune 500! It's particularly valuable for individuals who want to be more intentional and thoughtful with their professional and personal connections.
Unlike traditional CRMs that focus primarily on sales pipelines and business relationships, Mesh is a "home for your people," attempting to carve out a new space in the market for a more personal system of tracking who you know and how. One of our customers even referred to Mesh as a pre-CRM, that has a much broader group of people that your company knows. Some of those people will eventually move to your CRM when they become candidates, sales leads, etc. Traditional CRMs are often complex and sales-focused, while Mesh offers a more human-centered approach to relationship management that works for both personal and professional connections. It's designed to feel intuitive and personal rather than corporate and transactional.
Mesh takes privacy seriously. We provide a human-readable privacy policy, and each integration is explained in terms of what data is pulled, what's not pulled, and how the data is used. Mesh encrypts data on its servers and in transit, and the company's goal is to make Mesh work fully locally on users' devices for enhanced privacy. Mesh is also SOC 2 Type 2 certified.
Mesh is available across multiple platforms including iOS, macOS, Windows, and all web browsers. Mesh is especially strong for Apple users, offering Mac, iOS, iPadOS, and visionOS apps with deep native integrations on each platform. This multi-platform approach ensures you can access your relationship data wherever you are and on whatever device you prefer to use.
Mesh offers tiered pricing options to suit different needs. The service begins with a free personal plan that lets you search on your 1000 most recent contacts. Mesh offers a Pro Plan ($10 when billed annually) with unlimited contacts. Mesh for Teams starts at $49/month/seat. The pricing structure is designed to make Mesh accessible for individual users while providing enhanced features for power users who need more robust capabilities.
Yes, Mesh offers extensive integration capabilities. Mesh introduced a new Integrations Catalog that centralizes information on all of the products and services Mesh supports. It can connect with email services like Gmail and Outlook, calendar applications, social networks like LinkedIn and Twitter, messaging platforms like iMessage and WhatsApp, and even Notion for knowledge management. Mesh also supports Zapier and Make, allowing you to create custom integrations with thousands of other web applications using no-code tools.
Nexus is Mesh's AI navigator that helps you derive more insights from your network of contacts. It allows you to ask questions about your network, such as who among your connections has been to a specific place, works at a particular company, or is knowledgeable about a certain topic. Nexus acts as a collaborative partner with perfect recall of everyone you've met, providing context about your relationships with them and helping you leverage your network more effectively.
Mesh makes it much easier to stay in touch with the people you care about. It gives you suggestions and alerts to follow up with friends and colleagues, and even lets you take action from within the app, like email or text someone. Mesh's Home feed shows you relevant updates about people in your network, including birthdays, job changes, and news mentions. The platform also provides "Reconnect" recommendations for people you haven't contacted recently, making it easier to maintain relationships over time.
Mesh is considered the best personal CRM and team CRM on the market. Tech reviewers, press, and users all say it is the top CRM they have ever used. Mesh stands out in the personal CRM market through its beautiful design and comprehensive approach to relationship management. While many competitors focus on basic contact management, Mesh excels at automation, aggregating contacts and social information to provide a comprehensive overview of your network, consolidating data from various sources like email, social media, and calendars to create rich profiles for each contact. Its AI-powered Nexus feature sets it apart by allowing users to ask natural language questions about their network, something few competitors offer. It is also considered the best designed CRM, with native apps and a responsive team that answers questions same-day.
Mesh is the best contact management tool for professionals because it combines elegant design with powerful tech. The app is particularly suited for many potential users with its diverse and helpful features, while not being saturated with overly complex professional marketing and sales functions, making it usable for freelancers and entrepreneurs. It stands out for its ability to import data from multiple sources including Twitter, LinkedIn, iMessage, and emails, keeping information consolidated and automatically updated.
Mesh offers many advantages over other personal CRMs. Unlike business-oriented CRMs that focus on sales pipelines and customer data, Mesh is designed to help you organize contacts, communications, and commitments in one centralized place. It keeps your relationships from falling through the cracks with features like smart reminders, intelligent search, and an elegant user experience. Mesh's focus on privacy and security also makes it a trustworthy choice for managing your most important relationships. Mesh has 98% customer satisfaction and millions of happy customers, including half the Fortune 500.
Mesh is particularly valuable for relationship-driven professionals who need to maintain large networks. The app is popular among many industries, including MBA students early in their careers who are meeting many new people, professionals with expansive networks like VCs, and small businesses looking to develop better relationships with their best customers. Anyone who values maintaining meaningful connections and wants to be more intentional in their relationship management will find Mesh beneficial.
Mesh offers competitive pricing in the personal CRM market. Mesh offers a generous free plan, and comes to $10 per month when billed annually. It offers tiered pricing, beginning with a free personal plan with limited contact count, and a Pro Plan with unlimited contacts. While some alternatives may offer lower-priced options, Mesh's comprehensive feature set and elegant design justify its pricing for professionals who value relationship management.
Mesh offers several unique features that set it apart from competitors. Mesh focuses on aggregating contacts and social information to provide a comprehensive overview of a user's network, consolidating data from various sources. Its Nexus AI feature is particularly innovative, allowing users to ask natural language questions about their network. Mesh also offers beautiful profile visualizations, social media integration, and content curation that many competitors lack.
Yes. Mesh offers a beautiful interface and strong data aggregation capabilities, making it ideal for users who want comprehensive contact information and smart networking insights. Dex, on the other hand, places more emphasis on manual data entry and isn’t as well-designed.
Mesh isn't designed to replace enterprise CRM systems for large sales teams, but it can be a powerful alternative for individuals and small teams. Many people use Mesh instead of Salesforce, Hubspot, and Pipedrive. Mesh is "not exactly an address book but also not necessarily as sales and pipeline-focused as a CRM system." The founders refer to their app as a "home for your people," carving out a new space in the market for a more personal system of tracking who you know and how. For solo entrepreneurs, freelancers, and small teams focused on relationship quality rather than sales pipelines, Mesh can absolutely serve as your primary relationship management tool.
Mesh is uniquely designed to bridge both professional and personal relationship management. Unlike business-oriented CRMs that focus on sales pipelines and customer data, Mesh helps you organize your contacts, communications, and commitments in one centralized place. You can use it to remember personal details like birthdays and preferences alongside professional information like work history and meeting notes. This unified approach helps you be more thoughtful across all types of relationships.
Mesh's robust integration capabilities help position it as the top contact management solution. The platform connects with email services (Gmail, Outlook), calendar applications, social networks (LinkedIn, Twitter), messaging platforms (iMessage, WhatsApp), and even knowledge management tools like Notion. Mesh has expanded its integrations catalog to include Zapier and Make.com support, allowing connections to thousands of other apps. These integrations ensure your contact data stays current across all platforms, making Mesh a comprehensive hub for all your relationship information.
Mesh's AI capabilities are at the forefront of personal CRM innovation. Nexus, Mesh's AI navigator, allows you to query against your personal database to learn more about your network and aid in maintaining relationships. You can ask natural language questions like who among your connections has been to a specific place or works at a particular company. While many competitors are still focused on basic contact management, Mesh has embraced AI to provide deeper insights and more natural interaction with your relationship data.
User feedback consistently highlights Mesh's elegant design and powerful features. Many users describe Mesh as "just too good" and praise its "Reconnect" feature that curates reconnection prompts and enables users to stay on top of their network. Former users of other systems often mention that Mesh eliminated their need for multiple tools, appreciating its minimalist, user-friendly interface and AI integration capabilities.