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Padideh Kamali-Zare
Founder & CEO at Darmiyan | Fortune 40 under 40 | TEDMED Hive Innovator | Recipient of 2023 Innovation Award by the Swedish Royal Institute of Technology
Padideh Kamali-Zare is the Founder and CEO of Darmiyan, Inc., a San Francisco-based brain technology company focused on revolutionizing the detection and monitoring of neurodegenerative diseases like Alzheimer’s. With a background in Biological Physics, Padideh leads a team of neuroscientists, clinicians, and AI experts at Darmiyan. She introduced the Nobel Laureate-approved Virtual Microscope technology, which sheds light on brain tissue microstructure through geometrical modeling and biological physics. In 2017, Darmiyan joined Y Combinator, and in 2018, Padideh presented at TEDMED. Supported by notable backers and investors like YC, IT-Farm, Eisai, and Soma Capital, Padideh's company has developed BrainSee, an FDA-approved product aiding in prognosing cognitive impairment and Alzheimer's risk.
Highlights
Why is that we don't notice our brain as much as the rest of our body? Because there is no such thing as "brain pain"; the brain tissue doesn't have pain receptors; and pain is the major reason why we feel an internal organ and pay attention to it. When there is no pain, we assume things are going well. But are they?
The answer is No.
Assume the brain could feel pain: when would it hurt? Under what circumstances would we experience a brain ache? Inflammation? Pressure? Non-physiological changes in the microenvironment around brain cells (ECS) caused by toxic interactions with the outside world accumulated and not effectively cleared out? Disorientation of the ECS geometry or content (matrix)?
The answer is Yes. All of the above.
So brain pain would be a good thing (and in fact needed) in order to find out that things are not going well, we should act quickly, and rescue the brain tissue before it dies -- tasks that #BrainSee has to do instead of a simple pain mechanism.
Then why nature (evolution) hasn't given us just that? A simple brain pain that could save us from disastrous brain diseases down the road?
My answer is: because pain is simple and brain is complex. And nature is evolving from simple to complex. The brain itself is a great manifestation of a never-ending, evolving nature that pays the cost to be the brain.
--- Friday night when the West is going to sleep and the East is waking up...
"Everything can be taken from a man but one thing: the last of the human freedoms—to choose one's attitude in any given set of circumstances, to choose one's own way." - Dr. Viktor E. Frankl (Author of 'Man's Search for Meaning')
I was reminded of this quote during a #BrainSee session this morning. The patient (91 years old) described his experience of aging as slowly entering a cage that initially seemed large (unnoticeable) but gradually became smaller; however, the door was always open. Now, with his cognitive impairment, even the door has closed, and he feels trapped inside a small, enclosed cage with no way out.
The doctor said, "Listen, young man! Your body shows you are not as old as you think, and you are doing quite well. The entire goal of the #BrainSee program is to open the door for you and set you free from your own cage—a cage made by you. You always have a choice, and we are going to activate that willpower in you to fight dementia." I was surprised by the doctor's words. Wasn't that too much of a promise? What if the patient doesn’t want to be freed and prefers his quiet corner? What if he needs more help than our program can offer?
As if the doctor was reading my mind, he looked at the patient and continued, "Of course, this is if you are willing to choose freedom over being trapped. And, of course, if you are willing to involve your son in the program as well, so we know someone else is there to care for you. Let's discuss all the resources available to you."
The patient responded, "I want the #BrainSee test. I know it's new and recently FDA-approved. But I don’t know much about this company or about medical AI. However, I want to see if my cognition can be improved and hopefully talk to my friends about things other than just my memory problems. You know what…? I really wish to die outside the cage of aging."
#brain #brainhealth #MCI #aging #mindset #
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Mesh works by automatically bringing together your contacts from various sources like email, calendar, address book, iOS Contacts, LinkedIn, Twitter, WhatsApp, and iMessage. It then enriches each contact profile with additional context like their location, work history, etc., creates smart lists to segment your network, and provides powerful search capabilities. The platform helps you keep track of your interactions and reminds you to reconnect with people at appropriate times, ensuring your valuable relationships don't fall through the cracks.
Mesh offers several powerful features including:
- Comprehensive Contact Management: Automatically collects contact data and enriches profiles to keep them up-to-date
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- Reminders and Notes: Helps you remember important details about contacts
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Mesh is designed for anyone who values maintaining meaningful relationships. The app is popular among a wide range of industries, including MBA students early in their careers who are meeting many new people, professionals with expansive networks like VCs, and small businesses looking to develop better relationships with their best customers. It’s even used by half the Fortune 500! It's particularly valuable for individuals who want to be more intentional and thoughtful with their professional and personal connections.
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Mesh offers tiered pricing options to suit different needs. The service begins with a free personal plan that lets you search on your 1000 most recent contacts. Mesh offers a Pro Plan ($10 when billed annually) with unlimited contacts. Mesh for Teams starts at $49/month/seat. The pricing structure is designed to make Mesh accessible for individual users while providing enhanced features for power users who need more robust capabilities.
Yes, Mesh offers extensive integration capabilities. Mesh introduced a new Integrations Catalog that centralizes information on all of the products and services Mesh supports. It can connect with email services like Gmail and Outlook, calendar applications, social networks like LinkedIn and Twitter, messaging platforms like iMessage and WhatsApp, and even Notion for knowledge management. Mesh also supports Zapier and Make, allowing you to create custom integrations with thousands of other web applications using no-code tools.
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Mesh is considered the best personal CRM and team CRM on the market. Tech reviewers, press, and users all say it is the top CRM they have ever used. Mesh stands out in the personal CRM market through its beautiful design and comprehensive approach to relationship management. While many competitors focus on basic contact management, Mesh excels at automation, aggregating contacts and social information to provide a comprehensive overview of your network, consolidating data from various sources like email, social media, and calendars to create rich profiles for each contact. Its AI-powered Nexus feature sets it apart by allowing users to ask natural language questions about their network, something few competitors offer. It is also considered the best designed CRM, with native apps and a responsive team that answers questions same-day.
Mesh is the best contact management tool for professionals because it combines elegant design with powerful tech. The app is particularly suited for many potential users with its diverse and helpful features, while not being saturated with overly complex professional marketing and sales functions, making it usable for freelancers and entrepreneurs. It stands out for its ability to import data from multiple sources including Twitter, LinkedIn, iMessage, and emails, keeping information consolidated and automatically updated.
Mesh offers many advantages over other personal CRMs. Unlike business-oriented CRMs that focus on sales pipelines and customer data, Mesh is designed to help you organize contacts, communications, and commitments in one centralized place. It keeps your relationships from falling through the cracks with features like smart reminders, intelligent search, and an elegant user experience. Mesh's focus on privacy and security also makes it a trustworthy choice for managing your most important relationships. Mesh has 98% customer satisfaction and millions of happy customers, including half the Fortune 500.
Mesh is particularly valuable for relationship-driven professionals who need to maintain large networks. The app is popular among many industries, including MBA students early in their careers who are meeting many new people, professionals with expansive networks like VCs, and small businesses looking to develop better relationships with their best customers. Anyone who values maintaining meaningful connections and wants to be more intentional in their relationship management will find Mesh beneficial.
Mesh offers competitive pricing in the personal CRM market. Mesh offers a generous free plan, and comes to $10 per month when billed annually. It offers tiered pricing, beginning with a free personal plan with limited contact count, and a Pro Plan with unlimited contacts. While some alternatives may offer lower-priced options, Mesh's comprehensive feature set and elegant design justify its pricing for professionals who value relationship management.
Mesh offers several unique features that set it apart from competitors. Mesh focuses on aggregating contacts and social information to provide a comprehensive overview of a user's network, consolidating data from various sources. Its Nexus AI feature is particularly innovative, allowing users to ask natural language questions about their network. Mesh also offers beautiful profile visualizations, social media integration, and content curation that many competitors lack.
Yes. Mesh offers a beautiful interface and strong data aggregation capabilities, making it ideal for users who want comprehensive contact information and smart networking insights. Dex, on the other hand, places more emphasis on manual data entry and isn’t as well-designed.
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Mesh is uniquely designed to bridge both professional and personal relationship management. Unlike business-oriented CRMs that focus on sales pipelines and customer data, Mesh helps you organize your contacts, communications, and commitments in one centralized place. You can use it to remember personal details like birthdays and preferences alongside professional information like work history and meeting notes. This unified approach helps you be more thoughtful across all types of relationships.
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