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Samuel Breit

Director of Immunopathology and Staff Specialist in Clinical Immunology at St Vincent's Hospital, Sydney

Professor Samuel Norbert Breit is a Clinical Immunologist and Immunopathologist at St Vincent's Hospital Sydney and a Professor of Medicine at the University of New South Wales (UNSW).1 He heads the Inflammation and Cytokine Biology Research Program at St Vincent's Centre for Applied Medical Research.14

Prof Breit has a distinguished career in biomedical research, with over 160 publications in peer-reviewed journals.1 His expertise spans immunology, rheumatology, connective tissue diseases, cytokines, and biological response modifiers.1

Key contributions:

  1. Discovered and characterized two important molecules: the intracellular chloride ion channel protein CLIC1 and the divergent TGF-b superfamily cytokine MIC-1/GDF15.1
  2. Pioneered research on Growth Differentiation Factor 15 (GDF15), which plays a crucial role in regulating appetite, metabolism, and inflammation.2
  3. His work on MIC-1/GDF15 in cancer anorexia/cachexia and appetite regulation was recognized by the NHMRC as one of the "Ten best projects 2011".13

Prof Breit's current research focuses on understanding the central and peripheral mechanisms of MIC-1/GDF15 and its receptor GFRAL, particularly their effects on anorexia, metabolism, inflammation, and immunity.1 His work has potential applications in the diagnosis and management of cancer, cardiovascular disease, inflammatory diseases, obesity, and cancer-associated syndromes.1

Highlights

The GDF15-GFRAL Pathway in Health and Metabolic Disease
May 3 · svhs.org.au
St Vincent's Centre for Applied Medical Research
Feb 9 · youtube.com
Professor Samuel Breit - NHMRC Ten of the Best Research Projects ...
Professor Samuel Breit - NHMRC Ten of the Best Research Projects ...
Professor Samuel Norbert Breit - UNSW Research - UNSW Sydney

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Location

Greater Sydney Area