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Shanice Beerepoot

MD PhD candidate Child Neurology, Amsterdam Leukodystrophy Center, Amsterdam UMC

Shanice Beerepoot is an aspiring professional in the field of pediatric neurology with a strong interest in investigating the developing brain and its associated diseases. She aims to become a pediatric neurologist who can seamlessly integrate clinical practice, research, and education. Known for her reliability, hardworking nature, and practical hands-on approach, Shanice consistently strives for excellence in an efficient manner.

Highlights

Aug 24 · linkedin

🧠✨ Even though it’s Saturday evening, I couldn’t resist the satisfaction of ticking something off my to-do list. After a moment of meditation, I realized I still hadn’t shared some exciting news: our article on dendritic cell development in late-onset CSF1R-related disorder (CSF1R-RD)—previously known as adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP)—has been published in Molecular Immunology!

Key findings include:

  • CSF1R is crucial for the in vitro differentiation of conventional dendritic cells (cDCs) from CD34+ stem cells but is not essential for monocyte-derived DC development.

  • Patients with late-onset CSF1R-RD maintain all naturally occurring dendritic cell subsets in their peripheral blood, despite impaired CSF1R function.

  • In vivo compensation by other cytokines may explain the normal DC subsets seen in these patients.

Reflecting on my journey, it’s interesting how things come full circle. My first scientific internship in Amsterdam was all about dendritic cell vaccination. From there, I transitioned to Pediatric Neurology in Utrecht. And now, while working in Pediatric Neurology in Amsterdam, I’m writing about dendritic cell research conducted in Utrecht. 👩‍🔬

For those interested, the full article is freely accessible here: https://lnkd.in/e8FtTyf7

And, maybe more importantly, wishing you all a joyful weekend! 🎉

Aug 21 · linkedin

Our latest paper is now published in Clinical Neurology and Neurosurgery!🧠📄

Key findings from our research:

• Spontaneous improvement of large cysts and white matter edema may occur in leukoencephalopathy with calcifications and cysts (LCC).

• Recovery upon bevacizumab in individual LCC cases might be mistakenly attributed to drug effect.

• Understanding the LCC disease course requires a large-scale and long-term natural history study.

• Anecdotal drug effects must be validated by clinical trials before drawing conclusions.

You can read the full paper here (open access): https://lnkd.in/e6f5Nj4Y

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Shanice Beerepoot
Shanice Beerepoot, photo 1
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Location

Heerhugowaard, North Holland, Netherlands