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Dirk Fey

Group Leader, Research Fellow at Systems Biology Ireland

Dirk Fey is a systems biologist and Assistant Professor/Lecturer at University College Dublin (UCD), where he serves as a Group Leader and Principal Investigator at Systems Biology Ireland (SBI).456 His research focuses on dynamical mathematical modeling of biochemical networks, particularly in cancer biology, with an emphasis on signaling pathways and drug resistance mechanisms.36

Key Research Contributions

  • Cancer Signaling Networks: Investigated racial disparities in colorectal cancer between Black/African American and White patients using transcriptomic data and systems biology approaches to identify cohort-specific gene expression differences.1
  • Triple-Negative Breast Cancer (TNBC): Applied Bayesian Molecular Response Analysis (BMRA) to reconstruct kinase signaling networks in cisplatin-resistant TNBC cell lines, highlighting the PI3K/AKT pathway as a critical target for overcoming resistance.3
  • Cell Fate Dynamics: Collaborated on studies using mathematical models to predict how EGF hormone pulsing patterns influence cell differentiation in PC12 cells, demonstrating the importance of temporal signaling dynamics.2

Methodological Expertise

  • Systems Biology Approaches: Combines experimental data (e.g., RNA sequencing, reverse-phase protein arrays) with computational tools like BMRA and multivariable-adjusted regression to analyze signaling networks.13
  • Interdisciplinary Collaboration: Works with experimentalists and engineers to design microfluidic devices for controlled signaling perturbations.2

Academic and Professional Roles

  • Teaching: Holds a lecturer position at UCD, contributing to education in systems biology.5
  • Industry Collaboration: Previously worked on a joint project with AstraZeneca UK to study drug resistance mechanisms in cancer.2

His work bridges computational modeling and experimental biology to advance precision medicine strategies for cancer treatment.13

Highlights

Feb 10 · ucd.ie
Team - Systems Biology Ireland - University College Dublin
A Systems Biology Approach to Understand the Racial Disparities in ...
A Systems Biology Approach to Investigate Kinase Signal ...
Dec 10 · ucd.ie
Pulses of EGF Hormone Trick Cells Into Becoming Neurons

Related Questions

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How does Dirk Fey's work contribute to understanding cancer signaling networks?
What interdisciplinary approaches does Dirk Fey use in his research?
Can you explain the significance of the EGF hormone pulsing technique developed by Dirk Fey?
How does Dirk Fey's research impact precision medicine in cancer treatment?
Dirk Fey
Dirk Fey, photo 1
Dirk Fey, photo 2
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Location

Ireland